血浆BNP正常值的建立及其在心血管疾病中诊断截断点的探讨
正常值范围,,血浆脑钠肽；正常值范围；心血管疾病；诊断截断点,1材料与方法,结果,3讨论,【参考文献】
【摘要】 目的 建立西安地区健康人群血浆脑钠肽(BNP)的正常值范围，探讨BNP在心血管疾病中临床诊断截断点对心血管疾病诊断的可靠性。方法 采用微粒子酶免分析法，对西安地区健康人群血浆样本258份；不同心血管疾病患者血浆204份，进行血浆BNP浓度检测。结果 西安地区健康人群血浆BNP的正常值范围(微粒子酶免分析法)为0～38pg/ml；血浆BNP浓度冠心病组、心肌梗死组、心衰组的临床诊断截断点分别为4670pg/ml、7195pg/ml、11569pg/ml。各截断点对于相关疾病诊断的敏感性和特异性各不相同。不同心血管疾病组与正常组BNP浓度差异均有非常显著性(P<001)。结论 建立本地区健康人群血浆BNP浓度的正常值范围，对于本地区患者相关疾病的诊断具有重要实用价值；不同心血管疾病血浆BNP诊断截断点各不相同，诊断截断点的建立可提高心血管疾病诊断的准确率。【关键词】 血浆脑钠肽；正常值范围；心血管疾病；诊断截断点
Normal value range of plasma brain natriuretic peptide and study on diagnosis cut-off point of BNP levels in cardiovascular disease
PENG Dao-rong,XU Yan,ZHANG Xiao-ning,et al.
Department of Clinical Laboratories,Xijing Hospital,Xi’an 710032,China
【Abstract】 Objective To construct normal value range of plasma brain natriuretic peptide(BNP)in health adults from Xi’an area，study the clinical value of BNP levels as a diagnosis cut-off point for clinical diagnosis and therapeutic efficacy.Methods 258 plasma samples from health examination crowd and 204 plasma samples from cardiovascular disease patients had been selected to measure BNP levels by microparticle enzyme immunoassay.Results The normal value range of plasma brain natriuretic peptide (BNP)in health adults from Xian area were 0-38 pg/ml(microparticle enzyme immunoassay).The diagnosis cut-off point of BNP concentration in coronary heart disease,myocardial infarction,heart failure were 4670 pg/ml,7195 pg/ml,11569 pg/ml,respectively.There were significant differences in BNP levels among cardiovascular disease groups with normal group(P<001).Conclusion Normal value range of plasma brain natriuretic peptide (BNP)can use to diagnosis.Measuring of diagnosis cut-off point of BNP levels might be a potential as markers of cardiovascular disease. ......
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