【摘要】 目的 对甘利欣辅助治疗皮肌炎、系统性红斑狼疮的临床疗效及安全性进行临床评价。 方法 采用非盲法半随机对照法，试验组10例，对照组11例，均据病情需要使用激素，试验组辅以静滴甘利欣250～300mg/d，观察2～3周。 结果 皮肌炎、系统性红斑狼疮对照组的总有效率为72.7%，试验组为80%;但两组间差异无统计学意义(P>0.5)。皮损好转及生化酶学改变亦无统计学意义。不良反应轻微。 结论 甘利欣辅助治疗皮肌炎、系统性红斑狼疮的临床疗效尚需进一步研究。

    【关键词】 甘利欣;皮肌炎;系统性红斑狼疮

    Observation of18-а-glycyrrhizic acid as the adjuvant in the treatment of der-matomyositis and systemic lupus erythematosus

    LIWei，ZHOUGuong-ping，WEI Fa-rong，et al.

    Department of Dermatology，Huaxi Hospital，Sichuan Univer-sity，Chengdu610041，China

    【Abstract】 Objective To evaluate the curative effect and safety of18-а-glycyrrhizic acid as the adjuvant in the treatment of dermatomyositis，systemic lupus erythematosus.Methods A blind and half-random control testwas ap-plied.Both10cases in test group and11cases in control group were administerted with corticosteroid in need of dis-eases.And18-а-glycyrrhizic acid250mg～300mg via vessel per day for2～3weeks were brought into the test group.Results The total effective rate of control group was72.7% ......