胰腺癌组织 Survivin 与 Ki-67 的表达及其意义
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陈晓星, 倪金良, 郝 波, 张国新, 施瑞华,
Survivin;Ki-67;胰腺癌.陈晓星,倪金良,郝波,张国新,施瑞华,王学浩.胰腺癌组织Survivin与Ki-67的表达及其意义.世界华人消化杂志2005;13(22)2650-2653,胰腺
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陈晓星, 倪金良, 郝波,张国新, 施瑞华，南京医科大学第一附属医院消化科江苏省南京市 210029
王学浩，南京医科大学第一附属医院肝脏外科江苏省南京市210029
陈晓星,男, 1959-09-03生, 江苏省南京市人,汉族, 1989年上海第二医科大学硕士研究生毕业, 主任医师,主要从事胆胰疾病的基础和内镜诊治的研究.
国家自然科学基金资助项目, No.30400208
通讯作者：陈晓星,210029, 江苏省南京市广州路300号,南京医科大学第一附属医院消化科.chenxiao@public1.ptt.js.cn
电话: 025-83718836-6255
收稿日期：2005-08-06 接受日期：2005-08-26
Expression of Survivin and Ki-67 protein in human pancreatic cancer tissues and their clinical significances
Xiao-Xing Chen, Jin-Liang Ni, Bo Hao, Guo-Xin Zhang, Rui-Hua Shi, Xue-Hao Wang
Xiao-Xing Chen, Jin-Liang Ni, Bo Hao, Guo-Xin Zhang, Rui-Hua Shi, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Xue-Hao Wang, Department of Liver Transplantation, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to:Xiao-Xing Chen, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. chenxiao@public1.ptt.js.cn
Received:2005-08-06 Accepted: 2005-08-26
Abstract
AIM:To investigate the expression of an apoptosis inh-ibiting protein Survivin and a proliferation marker, Ki-67 in human pancreatic cancer tissues and their clinical significances.
METHODS:The expression levels of Survivin and Ki-67 protein were detected by immunohistochemical assay in human pancreatic cancer (n = 86) and their corresp-onding non-cancerous tissues (n = 78), and the clinico-pathological features were comparatively analyzed.
RESULTS:Survivin protein wasn’t expressed in tissu-es adjacent to either human pancreatic carcinomas or benign islet cell tumors, and the rate of Survivin expres-sion in pancreatic carcinomas was 87.9%, which was significantly higher than that in islet carcinomas (12 ......
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