壶腹癌组织中P-gp、LRP的表达及其意义
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金浩生, 周 杰, 阚和平, 廖彩仙, 谭远飞
P-糖蛋白;肺耐药相关蛋白;壶腹癌;免疫组化金浩生,周杰,阚和平,廖彩仙,谭远飞.壶腹癌组织中P-gp、LRP的表达及其意义.世界华人消化杂志2005;13(22)2714-27160引言,壶腹癌组织
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金浩生, 周 杰, 阚和平,廖彩仙, 谭远飞, 南方医科大学附属南方医院肝胆外科广东省广州市 510515
通讯作者：金浩生,510515, 广东省广州市,南方医科大学附属南方医院肝胆外科. kinghaos@yahoo.com.cn
电话：020-61687815
收稿日期：2005-09-21 接受日期：2005-09-30
Expression and clinical significance ofP-glycoprotein and lung resistance related protein in carcinoma of ampulla
Hao-Sheng Jin, Jie Zhou, He-Ping Kan, Cai-Xian Liao, Yuan-Fei Tan
Hao-Sheng Jin, Jie Zhou, He-Ping Kan,Cai-Xian Liao, Yuan-Fei Tan, Department of Hepatobiliary Surgery,Nanfang Hospital of Southern Medical University, Guangzhou 510515,Guangdong Province, China
Correspondence to: Hao-Sheng Jin, Department of HepatobiliarySurgery, Nanfang Hospital of Southern Medical University, Guangzhou510515, Guangdong Province, China. kinghaos@yahoo.com.cn
Received: 2005-09-21 Accepted: 2005-09-30
Abstract
AIM:To explore the expression and clinical significance ofP-glycoprotein (P-gp) and lung resistance related protein (LRP) in thecarcinoma of ampulla.
METHODS:Immunohistochemistry was used to detect theexpression of P-gp and LRP in the tissues from 39 patients with thecarcinoma of ampulla and 10 normal controls. The results and pathologicalfeatures were comparatively analyzed by statistical methods.
RESULTS: The positive expression of P-gp and LRP in the tissuesfrom the carcinoma of ampulla was significantly higher than that in thenormal controls (66.7%, 59.0% vs 20%, 10%, P < 0.05). Theexpression of P-gp and LRP had no relations with the sex, age, tumor size,and clinical stages. The expression of P-gp was positively correlated withlymph node metastasis (metastasis vs non-metastasis: 80.0% vs 42.9%, P <0.05) ......
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