胃癌组织KAI 1和nm23-H1蛋白的表达意义
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孟丽辉, 辛 彦, 吴东瑛, 张淑敏
KAI1;nm23-H1;胃癌;预后,胃癌组织KAI 1和nm23-H1蛋白的表达意义,孟丽辉,辛彦,吴东瑛,张淑敏,孟丽辉,通讯作者:,Clinicopathologicalsign
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孟丽辉, 辛彦, 吴东瑛, 张淑敏, 中国医科大学附属第一医院肿瘤研究所第四研究室 辽宁省沈阳市 110001
孟丽辉, 女, 1970-04-07生, 辽宁省沈阳市人, 汉族, 2001年中国医科大学肿瘤学硕士生, 主要从事胃癌方面研究.
国家自然基金项目资助项目, No.30371607
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤研究所第四研究室. yxin@mail.cmu.edu.cn
电话: 024-23256666-6351 传真: 024-22703576
收稿日期: 2005-05-22 接受日期: 2005-06-16
Clinicopathological significance of KAI 1 and nm23-H1 expression in gastric cancer
Li-Hui Meng, Yan Xin, Dong-Ying Wu, Shu-Min Zhang
Li-Hui Meng, Yan Xin, Dong-Ying Wu, Shu-Min Zhang, the Fourth Laboratory of the Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported by National Natural Science Foundation of China, No. 30371607
Correspondence to: Professor Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yxin@mail.cmu.edu.cn
Received: 2005-05-22 Accepted: 2005-06-16
Abstract
AIM: To investigate the expression of KAI 1 and nm23-H1 protein in gastric cancer, and to explore the clinicopath-ological significance of KAI 1 protein in the progression of gastric cancer.
METHODS: Eighty-seven paraffin-embedded specime-ns of gastric cancer were investigated immunohistoche-mically by Envision method with rabbit anti-human KAI 1 polyclonal antibody and mouse anti-human nm23-H1 monoclonal antibody. Statistical analysis was perform-ed using chi-square test.
RESULTS: The positive rate of KAI 1 expression in gastric cancer with lymph node metastasis (60%, 39/65) was significantly lower than that without lymph node metastasis (95%, 21/22, P <0.05), but the rate was markedly higher in early-stage tissues of gastric cancer than that in late-stage ones (94%, 16/17 vs 63%, 44/70, P <0.05). The patients with KAI 1 positive tumor tended to have a longer survival time (P <0 ......
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