当前位置: 首页 > 期刊 > 《世界华人消化杂志》 > 2005年第23期
编号:10924799
中西医结合治疗溃疡性结肠炎
http://www.100md.com 刘敬军, 郑长青, 潘丽丽, 闻 英, 胡刚正
溃疡性结肠炎;中西医结合;小鼠,刘敬军,郑长青,潘丽丽,闻英,胡刚正,通讯作者:,Experimentalresearchontreatmentofulcerativec
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     刘敬军, 郑长青, 潘丽丽, 闻英, 胡刚正, 中国医科大学第二临床学院 辽宁省沈阳市 110001

    通讯作者: 刘敬军, 110001, 辽宁省沈阳市和平区北二马路92号, 中国医科大学第二临床学院. shyljj@yahoo.com.cn

    电话: 024-23281706 传真: 024-23280417

    收稿日期: 2005-08-03 接受日期: 2005-10-27

    Experimental research on treatment of ulcerative colitis with integrative traditional Chinese and Western medicine

    Jing-Jun Liu, Chang-Qing Zheng, Li-Li Pan, Ying Wen, Gang-Zheng Hu

    Jing-Jun Liu, Chang-Qing Zheng, Li-Li Pan, Ying Wen, Gang-Zheng Hu, the Second Clinical College of China Medical University, Shenyang 110001, Liaoning Province, China

    Correspondence to: Jing-Jun Liu, the Second Clinical College of China Medical University, 92 Bei’er Road, Heping District, Shenyang 110001, Liaoning Province, China. shyljj@yahoo.com.cn

    Received: 2005-08-03 Accepted: 2005-10-27

    Abstract

    AIM: To explore the effect of the clyster treatment with integrated traditional Chinese and Western medicine on ulcerative colitis (UC), and to investigate its mechanism.

    METHODS: The mouse model of UC was established, and then the rats were treated (clyster) with the combination of tin-like powder, dexamethasone, gentamicin, and berberine. Then the therapeutic effect was observed, and the mechanism of the treatment was analyzed.

    RESULTS: The disease active index (DAI) and histopathologic score (HPS) of the low dose (DAI: 5.10±4.07, HPS: 8.00±6.38), the moderate dose (DAI: 0.80±1.87, HPS: 1.30±1.49), the high dose (DAI: 1.00±1.94, HPS: 0.90±1.45), and the positive control group (DAI: 5.30±4.37, HPS: 8.00±5.12) were markedly lower than those of the negative control group (DAI: 8.60±1.26, HPS: 13.20±1.69) (all P <0.05). The DAI and HPS of the moderate dose group were markedly lower than those of the low dose group and the positive control group (all P <0.05), but there was no significant difference between the moderate and high dose group (P >0.05). The levels of interleukin-4 (IL-4) of the low, moderate, and high dose group, and the positive control group were markedly lower than those of the negative control group (32 ......

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