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编号:10847010
肿瘤坏死因子α与2型糖尿病并牙周炎的关系探讨
http://www.100md.com 《中华现代内科学杂志》 2005年第12期
牙周炎,,牙周炎;糖尿病;肿瘤坏死因子α,1资料与方法,2结果,3讨论,【参考文献】
     【摘要】 目的 探讨血清TNF-α对2型糖尿病伴牙周炎患者的影响及其影响机制。方法 将选择的病例随机分为牙周基础治疗组(A组)和强化降血糖组(B组)各20例,观察12周,分别检查两组治疗前后体重指数、龈沟出血指数、探诊深度、糖化血红蛋白、总胆固醇、甘油三酯和血清肿瘤坏死因子α(tumor necrosis factor- alpha,TNF-α)的水平。结果 A组除体重指数和总胆固醇无显著变化外(P>0.05),PD、SBI、TNF-α、HbA1C和TG指标均显著降低,与治疗前相比差异有显著性(P<0.01)。而B组除糖化血红蛋白与治疗前比较差异有非常显著性外(P<0.01)。BMI、PD、SBI、TNF-α、CHOL和TG各项指标均无明显变化(P>0.05)。A组与B组治疗后比较,A组PD、SBI、TNF-α和TG明显低于B组(P<0.01),而BMI和CHOL无明显变化。结论 对于2型糖尿病伴牙周炎患者,牙周基础治疗可能通过降低患者血清TNF-α的含量而降低其糖化血红蛋白的水平。而通过强化降糖治疗不能改善牙周状况。

    【关键词】 牙周炎;糖尿病;肿瘤坏死因子α

    The relationship between TNF-α and type 2 diabetes patients with periodontitis

    WU Ying,WU Ming.

    Department of Endocrinology,The Third Affiliated Hospital of Jiangxi Medical College,Nanchang 330008,China

    【Abstract】 Objective To investigate the effect and mechanism of serum TNF-α on type 2 diabetes patients with periodontitis.Methods The patient were randomly divided into two groups: periodontal therapy group (A group ) and intensive reduced the blood glucose group (B group ). Their body mass index (BMI),sulcus bleeding index (SBI),probing depth (PD),glycolated hemoglobin (HbA1C),triglycerides (TG),cholesterol(CHOL) and tumor necrosis factor-alpha (TNF-α) concentration were determined before and 12 weeks after treatment.Results In A group compared with before therapy,PD,SBI,TNF-α,HbA1C and TG were reduced significantly (P<0.01),while there were no significant differences in BMI and CHOL value (P>0.05),In B group only HbA1C was reduced significantly (P<0.01),while there were no significant differences in BMI,PD,SBI,TNF-α,CHOL和 TG.The level of PD,SBI,TNF-α,TG in A group were significant lower than that in B group (P<0.01).But the change of BMI and CHOL between A and B group were not significant (P>0.05) . Conclusion Periodontal initial therapy can effectively reduce HbA1C value in type 2 diabetes patients with periodontitis,possibly through the reduction of TNF-α.The periodontitis were not improved by intensive reduced the blood glucose. ......

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