【摘要】 目的 研究银杏黄酮对三氯化铝所致痴呆模型大鼠学习记忆能力和海马内β-APP阳性神经元的影响，以期探讨银杏黄酮抗老年性痴呆的作用机制。方法 用三氯化铝致老年性痴呆模型大鼠为实验对象，以其学习记忆能力、背海马和齿状回内β-APP阳性神经元的数量为指标，全面考察银杏黄酮抗老年性痴呆的作用。结果 银杏黄酮(100、200、400mg/kg，ig)，能明显对抗老年性痴呆模型大鼠学习记忆能力的下降，抑制背海马和齿状回内β-APP阳性神经元的生成。结论 银杏黄酮对三氯化铝所致的老年性痴呆有明显的改善作用 。

    【关键词】 银杏黄酮；学习；记忆；小鼠

    The effects of Ginkgo flavone on Alzheimer’s model rats induced by AlCl3

    DOU Li-hua，MA Yu-kui，DING Yuan-sheng.

    Huxia Hospital of Shandong，Jinan 250031，China

    【Abstract】 Objective By using Alzheimer’s model rats induced by AlCl3，the effects and mechanism of Ginkgo flavone were investigated.Methods Ginkgo flavone were given to rats by oral for seven weeks.Then，the ability of study of mice were determined by step-down test and the number of neurons in the Bregma hippocampus containing β-APP proteins were counted.Results To the model rats ......