关键词: 心力衰竭，充血性;血瘀证;地高辛;药代动力学

    摘 要:目的 研究充血性心力衰竭(congestive heart fail-ure，CHF)血瘀证对地高辛药代动力学的影响. 方法 将充血性心力衰竭血瘀证患者按血瘀程度及心功能状况分为两组，第1组34例，血瘀较轻，心功能为Ⅰ～Ⅱ级，第2组38例，血瘀较重，心功能为Ⅲ～Ⅳ级，两组患者均口服地高辛片0.125～0.385mg d-1 ，用荧光偏振酶标免疫法检测地高辛的稳态血药浓度，同时以苦味酸法测定血清肌酐，用Bayesian一点法拟合地高辛的个体药动学参数，统计学比较两组患者地高辛药动学参数间差异. 结果 随着血瘀及心功能损伤的加重，地高辛的分布容积显著减少，清除率显著下降，AUC显著提高，血清中肌酐显著增高. 结论 地高辛在不同程度充血性心力衰竭血瘀证患者体内的药代动力学存在差异，肾功能衰减是造成差异的主要原因之一.

    Blood stasis in congestive heart failure bears rela┐tion with digoxin clinical pharmacokinetics

    WEN Ai-Dong，HUANG Xi，JIANG Yong-Pei，MEI Qi-Bing，ZHAO Lei，ZHANG Li

    1 Department of Pharmacy，

    2 Department of Tradi-tional Chinese Medicine，Xijing Hospital，

    3 Depart-ment of Pharmacology，Faculty of Preclinical Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:heart failure，congestive;blood stasis;digoxin;pharmacokinetics

    Abstract:AIM To study the influential factors in patients with congestive heart failure blood stasis on clinical pharma-cokinetics of digoxin.METHODS Patients with congestive heart failure blood stasis were divided into two groups ac-cording to blood stasis degree and heart function.The first group(heart functionⅠ～Ⅱ)included34cases with light blood stasis ......