【摘要】 目的 应用新型超声造影剂声诺维(SonoVue)与实时造影匹配成像技术(CnTI)，观察超声造影对肝血管瘤的灌注及回声变化规律，探讨肝血管瘤的增强模式。方法 用CnTI技术对40例75个肝血管瘤病灶施行超声造影，观察注射造影剂后肝血管瘤在动脉期(0～40s)、门静脉期(41～120s)及延迟期(121～360s)的增强情况。结果 75个病灶均在动脉期出现增强，回声高于肝实质，在门脉期和实质期病灶持续强化，其中23(31%)个病灶在动脉期呈周边结节状强化，随后进行性向心性填充，19个病灶完全填充，4个病灶未完全填充；22(29%)个病灶为环状强化，随后进行性向心性强化并完全填充；30(40%)个病灶在动脉期呈整体快速强化，门脉期和延迟期呈持续等高回声。结论 超声造影肝血管瘤增强模式的主要特点为动脉期从周边结节状、环状或整体快速强化开始，门脉期和延迟期持续向心性进行性增强或持续呈等高回声。

    【关键词】 肝；血管瘤；造影剂；超声检查；实时造影匹配成像技术

    Diagnosis of liver haemangiomas with a novel contrast medium SonoVue and real time gray-scale contrast tuned imaging technology

    YANG Xue-ying,KANG Chun-song,YANG Yong-sheng,et al.

    Department of Ultrasonography,The Hospital of Central North China University,Taiyuan 030051,China

    【Abstract】 Objective To investigate the perfusion and echogenicity of liver haemangiomas by using contrast medium SonoVue and real time gray-scale contrast tuned imaging technology and to discuss the enhancement pattern of liver haemangioma at gray-scale contrast-enhanced ultrasonography(CEUS).Methods With bolus injection of SonoVue via peripheral vein and real time gray-scale contrast tuned imaging technology(CnTI),40 patients with 75 foci of liver haemangioma underwent contrast-enhanced examination.Scanning enhancement pattern of liver haemangiomas were observed at arterial phase(0～40s),portal phase(41～120s)and lag phase(121～360s).Results All 75 lesions were enhanced and presented hyperechoic in arterical phase.In portal phase and lag phase lesions were persistently enhanced while 23(31%) haemangiomas showed peripheral hyperechoic nodules in arterial phase,followed by progressive centripetal fill-in,which was complete in 19 foci and incomplete in 4 cases.22(29%) haemangiomas showed a rim of arterial contrast enhancement with progressive and complete centripetal fill-in in portal and phases.Finally,30(40%) haemangiomas showed rapid and complete fill-in in arterial phase,which persisted in portal and lag phases.Conclusion In contrast-enhanced ultrasound the characteristic enhancement pattern of liver haemangioma is shown peripheral hyperechoic nodules、a rim-like or rapid and complete enhancement in arterial phase and the enhancement was persistent or iso-hyperechoic in portal phase and lag phase. ......