罗格列酮对大鼠溃疡性结肠炎肠黏膜NF-κB, ICAM-1表达的影响
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周静平, 邓长生
溃疡性结肠炎;罗格列酮;核转录因子-κB;细胞间黏附分子-1,罗格列酮对大鼠溃疡性结肠炎肠黏膜NF-κB,ICAM-1表达的影响,周静平,邓长生,通讯作者:,Effectsofrosiglitazo
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周静平, 邓长生, 武汉大学中南医院消化内科 湖北省武汉市 430071
通讯作者: 邓长生, 430071, 湖北省武汉市武昌区东湖路169号, 武汉大学中南医院消化内科
电话: 027-87331114
收稿日期: 2005-10-25 接受日期: 2005-10-31
Effects of rosiglitazone on expression of NF-κB and ICAM-1 in rats with ulcerative colitis
Jing-Ping Zhou, Chang-Sheng Deng
Jing-Ping Zhou, Chang-Sheng Deng, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Correspondence to: Chang-Sheng Deng, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China
Received: 2005-10-25 Accepted: 2005-10-31
Abstract
AIM: To investigate the effect of rosiglitazone on the expression of nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) in the colon mucosa of rats with ulcerative colitis.
METHODS: The rat colitis model was induced by the combined enema of trinitrobenzene sulphonic acid (TNB) and ethanol. The experimental animals were randomly divided into six groups: normal group, model group, Sulfasalazine (SASP) group (100 mg/kg), and 3 rosiglitazone groups (2, 4, 8 mg/kg). The saline, SASP, and different concentrations of rosiglitazone were administered by gastric irrigation daily, respectively, from 24 h after the establishment of model to the end of experiment. The disease activity index (DAI) and colon mucosa damage index (CMDI) of the rats were observed and evaluated. The activity of myeloperoxidase (MPO) was measured by biochemical method. The expression of NF-κBp65 and ICAM-1 protein were detected by immunohistochemistry.
RESULTS: As compared with the normal group, the DAI, CMDI, and the activity of MPO in the colon tissues of the rats in the model group were significantly increased (2.11 ± 1.29 vs 0.11 ± 0.17; 2.67 ± 0.82 vs 0.33 ± 0.52; 1.26 ± 0.36 U/g vs 0.27 ± 0 ......
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