内毒素性急性肝损伤实验动物模型的建立
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刘亮明, 邓 欢, 张吉翔, 罗 杰
内毒素;急性肝损伤;动物模型;凋亡,刘亮明,邓欢,张吉翔,罗杰,刘亮明,通讯作者:,Establishmentoflipopolysaccharide-ind
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刘亮明, 邓欢, 张吉翔, 罗杰, 南昌大学第二附属医院消化内科、江西省分子医学重点实验室 江西省南昌市 330006
刘亮明, 男, 1968-02-04生, 江西省瑞金市人, 汉族, 副主任医师, 副教授, 主要从事消化系疾病基因治疗的基础和临床研究.
国家自然科学基金项目, No.30160032, No.30360037
江西省科委重点项目, No.200110300101, No.20041B0300300
通讯作者: 张吉翔, 330006, 江西省南昌市, 南昌大学第二附属医院消化内科. jixiangz@tom.com
电话: 0791-6292706
收稿日期: 2005-10-25 接受日期: 2005-10-31
Establishment of lipopolysaccharide-induced acute liver injury in rats
Liang-Ming Liu, Huan Deng, Ji-Xiang Zhang, Jie Luo
Liang-Ming Liu, Huan Deng, Ji-Xiang Zhang, Jie Luo, Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University; Jiangxi Provincial Key Laboratory of Molecular Medicine, Nanchang 330006, Jiangxi Province, China
Supported by National Natural Science Foundation of China, No.30160032, No.30360037, and the Key Project of Science and Technology Committee of Jiangxi Province, China, No.200110300101, No.20041B0300300
Correspondence to: Ji-Xiang Zhang, Department of Gastroenterology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. jixiangz@tom.com
Received: 2005-10-25 Accepted: 2005-10-31
Abstract
AIM: To study the lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN) sensiti-zed rats at a sub-lethal dose.
METHODS: Forty eight rats were randomly divided into three groups (16 for each). The rats in each group were further divided into model (n = 8) and control group (n = 8). The rats in the model group received intraperitoneal injections of LPS (50 μg/kg) and D-GalN (300 mg/kg) in 1 mL stroke-physiological saline solution (SPSS), while the rats in the control group were treated with SPSS only. The tissue and blood samples were collected at 6, 24, and 48 h, respectively. The contents of serum alanine aminotransferase (ALT), aspartate transaminase (AST) and total bilirubin (TBIL) were detected ......
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