关键词: 人乳头瘤病毒;胃肿瘤;聚合酶链反应;病因学

    中图号:R735.2

    摘 要:目的 研究西安地区人乳头瘤病毒(HPV)的感染与胃癌的关系. 方法 运用PCR方法，同时设计HPV共同引物和HPV16型和HPV18型巢式引物，对胃癌组织(n=40)、癌旁组织和非肿瘤组织(n=10)进行HPV DNA的检测. 结果 胃癌40例组织中HPV检出15例，总检出率为37.5%;癌旁组织和非肿瘤组织未检出.HPV的检出以HPV16型为主，占检出阳性的80.0%，且与癌组织的分化程度密切相关. 结论 HPV的感染，主要为高危型HPV16型的感染与本地区胃癌的病因学可能关系密切.

    Significance of human papillomavirus infection in gastric carcinoma

    ZHANG Wei-Long，LI Chen-Hao，XIAO Bing，DING Jie，MIAO Ji-Yan，FAN Dai-Ming

    Institute of Gastrointerstinology of Chinese PLA，Xijing Hospital，Fourth Military Medical Universi-ty，Xi'an710033，China

    Keywords:human papillomavirus;stomach neoplasms;poly-merase chain reaction;etiology

    Abstract:AIM To study the relationship between HPV in-fection and gastric carcinoma in Xi'an area.METHODS Polymerase chain reaction(PCR)method was used in this study to detect the HPV DNA sequences in gastric carcinoma tissue.RESULTS Of40cases of gastric carcinoma tissues，15were found HPV positive，with a detection rate of37.5%.No HPV was detected in para-cancerous and non-tumorous tissues.Those detected in gastric carcinoma groups were mainly of type16 ......