关键词: 卵巢切除术;骨质疏松;选择性雌激素受体调节剂;他莫昔芬;骨密度

    摘 要:目的 选择性雌激素受体调节剂对去势大鼠松质骨、皮质骨骨密度的影响. 方法 将21只SD大鼠随机分为3组，每组7只，A组为对照组，B组为去势组，C组为去势+他莫昔芬组，在去势后5wk给药.术后16wk处死各组大鼠，进行离体骨密度(bone mineral density，BMD)测量及组织形态学测量. 结果 ①与对照组相比，去势组去势后16wk股骨头、股骨颈、股骨干、肱骨头、肱骨干、腰椎BMD明显降低(P<0.01);骨小梁体积、骨小梁厚度、椎体皮质骨厚度、结连结密度、结密度亦明显降低(P<0.05)而游离端密度和结连游离端密度增高(P<0.01);②他莫昔芬治疗后11wk，各部位BMD增加(P<0.05)但没有恢复到正常水平(P<0.05);腰椎骨小梁连接性参数恢复到对照组水平(P>0.05). 结论 ①去势后16wk大鼠松质骨、皮质骨骨量均明显下降，腰椎骨小梁三维结构破坏，骨小梁连结程度降低;②他莫昔芬治疗后，松质骨、皮质骨骨量均明显增加，但没有恢复到去势前水平;③他莫昔芬能增加腰椎椎体皮质骨厚度，增加腰椎骨小梁厚度.增加皮质骨、松质骨骨量;还可提高腰椎微构筑的质量，使骨小梁连结程度增加.

    Influence of tamoxifen on bone mineral density of cancellated bone and compact bone in ovariec┐tomized rats

    MENG Xiang-De，LIN Ya-Ping ，LIU Jian

    1 Institute of Orthopedics of Chinese PLA，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，2 Department of Surgery，518Hospital of Chinese PLA，Xi'an710032，China

    Keywords:ovariectomy;osteoporosis;selective estrogen re-ceptor modulator;bone density;tamoxifen

    Abstract:AIM To discuss the influence of selective estro-gen receptor modulator(SERM)on bone mineral density loss in cancellated bone and compact bone of ovariectomized rats.METHODS Twenty-one female SD rats were divided into three groups(7rats per group).Bilateral ovariectomies were done on group B and C.Sham operation was done on group A.Group C was treated with tamoxifen5weeks later.Six-teen weeks after operation ......