关键词 :T淋巴细胞;超敏反应，迟发型;淋巴细胞转化;淋巴细胞亚群;免疫，细胞

    摘 要:目的 观察墨旱莲乙酸乙酯总提物(EAEEP)对T淋巴细胞介导的细胞免疫的影响. 方法 采用正常小鼠及腹腔注射环磷酰胺造成免疫功能低下小鼠模型，观察EAEEP对外周血CD4

    + ，CD8+ T淋巴细胞亚群比例、迟发性超敏反应(DTH)、ConA刺激的淋巴细胞增殖反应的影响. 结果 EAEEP显著抑制正常小鼠的细胞免疫功能(正常组CD4+ T淋巴细胞比例为40.13%，EAEEP大剂量组降至30.87%)，而对于免疫功能低下模型鼠可显著促进细胞免疫功能(使免疫抑制组CD4+ T淋巴细胞比例由34.87%升至40.80%). 结论 墨旱莲乙酸乙酯总提物对T淋巴细胞介导的细胞免疫具有一定的免疫调节作用.

    Effect of ethyl acetate extract of Eclipta prostrata on the function of T lymphocyte

    LIU Xue-Ying，ZHAO Yue-Ping，JIANG Yong-Pei，TANG Hai-Feng

    1 Department of Pharmaceutics，Tangdu Hospital，Xi'an710038，

    2 Department of Pharmaceutics，Xijing Hospital，Fourth Military Medical University

    Keywords:T-lymphocytes;hypersensitivity delayed;lympho-cyte transformation;lymphocyte subsets;immuni-ty，cellular

    Abstract:AIM To explore the effect of Ethyl acetate ex-tract of Eclipta prostrata on cellular immunity in mice.METHODS The experimental immunosuppressive mice models were induced by injection of cyclophosphamide.EAEEP was given to the normal and model mice by gastro-gavage for6days to observe the effect of EAEEP on the pro-portion of T lymphocyte subsets ......