关键词 :轮状病毒属;感染;心脏;病毒血症

    摘 要:目的 为了了解轮状病毒(RV)腹泻患儿心脏受累的可能性以及与临床表现及病毒血症等相关因素的关系. 方法 检测RV腹泻患儿44例血清心型激酶(CK-MB)、谷草转氨酶(AST)值，并将CK-MB的变化与相关临床表现等进行多因素分析;以反转录-套式PCR方法检测RV腹泻组患儿外周血血清和单个核细胞中的RV基因组. 结果 RV腹泻患儿44例中，CK-MB异常者25例(57%)，其中22例(50%)为282～498nkat·L-1 ，3例(7%)为650～1300nkat·L-1 ;AST异常者36例(82%)，其中24例(55%)为783～1466nkat·L-1 ，4例(9%)为1510～2075nkat·L-1 ，7例(16%)为2633～6800nkat·L-1 .腹泻、脱水与酶学增高无显著相关，发热程度与之密切相关.检测到病毒血症4例，其中血浆中1例，外周血单个核细胞中3例. 结论 在RV腹泻普通人群中也可能出现肠道外感染，心脏可能是受损器官之一.妥善处理腹泻脱水大量补液与潜在心功能低下之间的矛盾是十分必要的.

    Co┐relative factors between heart lesion and viremia in young children with rotavirus diarrhea

    LI Ning，YAO Ying-Min，WANG Zhi-Rui

    1 Department of Pediatrics，Nanfang Hospital，First Military Medical University，Guangzhou510515，China;

    2 Department of Pharmacon，Xijing Hospital，Fourth Military Medical University

    Keywords:rotavirus;infection;heart;viremia

    Abstract:AIM To investigate the possibility of myocardial involvement in children with rotavirus(RV)diarrhea and its association with clinical manifestations and viremia resulting from RV infection.METHODS Levels of creatine kinase-MB(CK-MB)and aminotranferase(AST)in the serum of children with RV diarrhea were measured and multi-factor analysis was performed to explore the correlation between changes in CK-MB level and the clinical manifestations.The genome of RV from blood serum and mononuclear cells were tested with reverse-nest polymerase chain reaction.RE-SULTS For CK-MB ......