【摘要】 目的 探讨子宫腺肌病(腺肌病)患者在位子宫内膜中血管内皮生长因子受体(VEGFR)KDR的表达及意义。方法 采用免疫组化(SABC法)方法，检测11例腺肌病患者在位子宫内膜组织(腺肌病组)及30例非内异症患者的正常子宫内膜组织(正常内膜组)中VEGF受体KDR的表达差异。结果 (1)腺肌病在位内膜及正常内膜KDR受体阳性表达率分别为81.81%、76.67%。(2)腺肌病在位内膜腺上皮细胞在增生期、分泌期阳性表达强度分别为(++)和(+++)，较正常内膜组相应时期的(+～++)和(++～+++)有一定增高。结论 腺肌病组中KDR受体的明显表达可能与KDR受体参与腺肌病血管生成，促使子宫内膜侵入基层生长有关；也提示基底层子宫内膜侵入基层与卵巢激素相关。

    【关键词】 子宫腺肌病；血管内皮生长因子受体；正常子宫内膜

    Expression of vascular endothelial growth factor receptors kinase insert domain-contaning receptor in adenomyosis

    NI Ma-zhuo-ma，ZHANG Shao-feng,LI Ya-li,et al.

    Department of Obstetrics and Gynecology,Hospital of CPAF,Tibet 850000,China

    【Abstract】 Objective To detect the expression of vascular endothelial growth factor receptors KDR(kinase insert domain containing receptor) in the eutopic of patients with adenomyosis and human normal endometrium.Methods Eleven specimens of eutopic endometrium was biopsied from patients with adenomyosis,another 30 specimens of endometrium were biopsied from women without immunohistochmistry(Strept avidin-biotin complex,SABC)analysis was utilized to examine KDR and flt-1 protein expression and their levels in the above endometrium.Results KDR and flt-1 expressed higher level than human normal endometrium.Conclusion The VEGF receptors KDR and flt-1 highly expressed in eutopic endometrium of women with adenomyosis,showed the expression of VEGF receptors KDR and flt-1 in adenomyosis might be related to the development of adenomyosis; also related to the estrogen and gestagen. ......