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编号:10857196
Explore of allogenic melanocytes transplantation on vitiligo
http://www.100md.com 《第四军医大学学报》 2001年第24期
transplantation,Exploreofallogenicmelanocytestransplantationonvitiligo,INTRODUCTION,MATERIALSANDMETHODS,RESULTS,DISCUSSION,REFERENCES
     Keywords:transplantation,homologous;melanocytes;vitili-go

    CLC number:R758.41

    Abstract:AIM To study the feasibility of vitiligo treatment through allogenic transplantation of pure melanocytes.METHODS By negative pressure suction blisters were made at a female vitiligo volunteer's lesions.Suspension of pure cultured melanocytes from a healthy male donor was injected into the blisters.The effects in appearance were observed continuously.The outcome of the allogenic melanocytes was determined by pathological examination and specific fragment of Y chromosome detection.After color-recovery were ob-served at the transplanted areas,ten volunteers joined the test too.RESULTS The four transplanted spots'colors of the first female transplanter appeared some re-pigmentation1mo after transplantation.The transplant spots'colors were almost identical to those of adjacent normal skin2mo later.One hundred and sixty days later pathological examination of one repigmented spot displayed that there were melanocytes that could secrete melanin into adjacent keratinocytes.Y chromosome fragment was detected positive in the DNA ex-tracted from the skin of another repigmented spot.Two hun-dred days after second grafting one transplanted spot showed obvious color-recovery too.Similar results were observed in some of other transplanted patients.CONCLUSION Be-cause the allogenic melanocytes can survive in acceptor graft-ing of cultured allogenic melanocytes and can repiment vitiligo lesions and it is promising to develop a new way to treat vi-tiligo. ......

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