关键词: 肿瘤;癌胚抗原;半衰期;复发;肿瘤转移

    摘 要:目的 观察恶性肿瘤患者血清癌胚抗原(CEA)半衰期(T

    1/2 )在术后监测中的意义. 方法 应用单克隆双抗体夹心酶免疫一步法分别检测治疗前、后血清CEA. 结果 治疗后血清CEA预测恶性肿瘤复发或转移的敏感性，特异性和总符合率(准确度)分别为56%，82%和77%，而CEA半衰期T1/2 >15d时分别高达89%，94%和93%. 结论 血清CEA T1/2 检测优于CEA测定，术后残余癌细胞越多CEA T1/2 越长，故CEA T1/2 是恶性肿瘤复发转移早期极敏感的监测指标. Significance of serum carcinoembryonic antigen bio┐logical half┐life for patients with malignant tumors

    LIU Shu-Lin，QI Wei-Min，ZHANG Li-Jun，ZHAO Yi

    Department of Clinical Laboratory，Tangdu Hospi-tal，Fourth Military Medical University，Xi'an710038，China

    Keywords:neoplasms;carcinoembryonic antigen;half-life;recurrence;neoplasms metastasis

    Abstract:AIM To study the meaning of serum carcinoem-bryonic antigen(CEA)biological half-life(T1/2 )for the pa-tients with malignant tumors.METHODS CEA contens in serum were determined by one step double sandwich ELISA.RESULTS Sensitivity ......