关键词: 聚酯;分子结构;生物降解;材料试验

    摘 要:目的 探讨几种新型可生物降解聚酯类合物的结构及生物环境对降解规律的影响，为临床选择应用该类材料提供实验依据. 方法 将自行合成的聚己内酯(PCL)、聚丙交酯(PLA)、以及它们不同摩尔比的共聚物(PCLA2/1，PCLA1/2)分别置于胆汁、胰组织悬液和血浆中1～7d，植入兔肌肉内24wk，观察材料质量损失、超微形态变化和分子量变化. 结果 PCL在24wk内各种性质变化最慢:质量损失不明显，分子质量在胰腺悬液中下降19.8%，形态无明显变化;PCLA2/1在24wk时质量损失0.5%，分子质量下降61.7%，材料断面出现蚀刻形态;PCLA1/2在24wk质量损失40.4%，分子质量下降6.6%，形态出现空洞、碎裂;PLA在24wk质量损失79.2%，分子质量下降15.1%，形态完全降解. 结论 不同结构的材料在不同环境中体现不同的降解性质.

    Biodegradation of new variant┐structure polyesters

    SUN Lei，LIANG Qi-Zhi，GAN Zhi-Hua，YU Dong-Hong，XU Xin-Xiang，JING Xia-Bin

    1 Orthopaedic and Trauma Institute of PLA，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China，

    2 Changchun Institute of Ap-plied Chemistry，Changchun130022，

    3 Orthopaedics Department of First Clinic College，Bethun Univer-sity of Medical Science，Changchun130021

    Keywords:polyester;molecular structure;biodegradation;marterial testing

    Abstract:AIM To examine the effect of molecular structure and the bioenvironmental influence on new-type biodegrad-able polyesters in order to support the clinical application with laboratorial data.METHODS Homemade polyesters of variant molecular structures and poly-ε-caprolacton PCL;poly-DL-lactic acid PLA;and two kinds of their copolymer PCLA1/2and PCLA2/1)were dipped in gall ......