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编号:10857529
Combined use of rhBMP2/BCB and vascularized periosteum in repair┐ing s
http://www.100md.com 《第四军医大学学报》 2001年第11期
bone,morphogenetic,protein,,骨形态发生蛋白;骨移植;移植,异种;骨膜,CombineduseofrhBMP2,BCBandvascularizedperiosteuminrepair┐ingsegmentaldefectsinradiiofrabbits,INTRO
     Keywords:bone morphogenetic protein;bone transplanta-tion;transplantation,heterologous;periosteum CLC number:R686.34 Document code:A

    Abstract:AIM To study the efficacy of rhBMP2/BCB used alone and combined use of rhBMP2/BCB and vascularized pe-riosteal graft in repairing segmental bony defects.METHODS A new grafting material(rhBMP2/BCB)was made by combining recombinant human BMP2(rhBMP2)and an anti-gen-free bovine cancellous bone(BCB)as a carrier.rhBMP2/BCB was used alone,in conjunction with vascular-ized periosteal graft to repair a1.5cm defect in the radius of the rabbit.The defect-repairing capability for each of the treatment modalities was assessed radiographically,biome-chanically,by densitometry and histological studies.RESULTS ①rhBMP2/BCB used alone was capable of heal-ing the defect in large part by16wk,with a similar repair process and mechanism to that seen with RBX;②use of rhBMP2/BCB in conjunction with vascularized periosteal graft exhibited stronger defect-repairing power,basically healing the defect by8wk.The repair process consisted of intramembranous and endochondral ossification that resem-bled the physiological repair during the fracture healing.CONCLUSION Both methods are effective in repairing seg-mental bony defects ......

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