慢性乙型肝炎患者高迁移率族蛋白1mRNA的表达及其临床意义
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彭建平, 范学工, 刘洪波
高迁移率族蛋白1;慢性乙型肝炎彭建平,范学工,刘洪波.慢性乙型肝炎患者高迁移率族蛋白1mRNA的表达及其临床意义.世界华人消化杂志2006;14(2)167-172,慢性乙型肝炎患者高迁移率族蛋白1m
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彭建平, 范学工, 刘洪波, 中南大学湘雅医院感染病科 湖南省长沙市 410008
彭建平, 女, 1979-10-13生, 湖南华容人, 汉族, 2003年湘雅医学院本科毕业, 现为湘雅医院2003级在读硕士研究生.
通讯作者: 范学工, 410008, 湖南省长沙市, 中南大学湘雅医院感染病科. xgfan@hotmail.com
电话: 0731-4327392 传真: 0731-4327332
收稿日期: 2005-11-08 接受日期: 2005-12-02
Expression of high mobility groupbox-1 protein mRNA in patients with chronic hepatitis B and its clinicalsignificance
Jian-Ping Peng, Xue-Gong Fan, Hong-BoLiu
Jian-Ping Peng, Xue-Gong Fan, Hong-BoLiu, Department ofInfectious Diseases, Xiangya Hospital of Central South University,Changsha 410008, Hunan Province, China
Correspondence to: Xue-Gong Fan, Department of Infectious Diseases,Xiangya Hospital of Central South University, Changsha 410008, HunanProvince, China. xgfan@hotmail.com
Received: 2005-11-08 Accepted:2005-12-02
Abstract
AIM:To investigate the expression and clinical significance of high mobility group box-1 protein (HMGB1) mRNA in chronic hepatitis B.
METHODS:The expression of HMGB1 mRNA was detected in peripheral blood mononuclear cells (PBMCs) of 54 patients with chronic hepatitis B and 10 normal controls by reverse transcription-polymerase chain reaction (RT-PCR). The levels of plasma tumor necrosis factor-a (TNF-a) and lipopolysaccharide (LPS) were measured by enzyme linked immunosorbent assay (ELISA) simultaneously. The levels of total bilirubin (TBIL) prothrombin time activity percentage (PTA) were examined by biochemical methods.
RESULTS:HMGB1 mRNA expression was significantly increased in severe hepatitis patients in comparison with that in chronic hepatitis B patients and normal controls (0.89±0.06 vs 0.70±0.10, 0.58±0.08, P <0.01). Marked difference also existed between the latter two (0.70±0.10 vs 0.58±0.08, P <0.01). Of the 23 patients with chronic severe hepatitis, the HMGB1 mRNA levels in 11 unrecovered patients were notably higher than those in 12 recovered patients (0 ......
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