促甲状腺激素释放激素在应激性溃疡致病过程中的作用
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郭益民, 李 旭, 陈 然, 夏钦贵
促甲状腺激素释放激素;应激性溃疡;侧脑室郭益民,李旭,陈然,夏钦贵.促甲状腺激素释放激素在应激性溃疡致病过程中的作用. 世界华人消化杂志2006;14(2)216-219,促甲状腺激素释放
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郭益民, 李旭, 陈然, 夏钦贵,温州医学院生理学教研室 浙江省温州市325035
温州市科学技术委员会基金资助项目,No. 00010
通讯作者: 郭益民, 325035, 浙江省温州市温州医学院生理学教研室. gym@wzmc.net
电话: 0577-86689769
收稿日期: 2005-11-08 接受日期: 2005-12-02
Role of thyrotropin-releasing hormone in formation ofstress ulcer
Yi-Min Guo, Xu Li, Ran Chen, Qin-Gui Xia
Yi-Min Guo, Xu Li, Ran Chen, Qin-GuiXia, Department of Physiology, Wenzhou Medical College, Wenzhou325035, Zhejiang Province, China
Supported by the Fund from Wenzhou Science and TechnologyCommittee, No. 00010
Correspondence to: Yi-Min Guo, Department of Physiology, WenzhouMedical College, Wenzhou 325035, Zhejiang Province, China. gym@wzmc.net
Received: 2005-11-08 Accepted: 2005-12-02
Abstract
AIM: To investigate the role ofthyrotropin-releasing hormone (TRH) in the rat ulcer induced bycold-restraint stress and its possible mechanism.
METHODS: Therat model of stress ulcer was constructed by cold-restraint method. Thechanges of gastric mucosa, gastric juice secretion, and gastric motilitywere evaluated after injection of TRH or TRH antiserum into the lateralventricle.
RESULTS: Threehours after the administration of TRH, severe damages were observed in thegastric mucosa of rats fasting for 24 h at room temperature. As comparedwith the control group, the volume of gastric juice secretion (5.5 ± 0.7mL/2 h vs 2.7 ± 0.6 mL/2 h, P < 0.01) and total acidoutput (539.4 ± 50.5 molHCl/2 h vs 317.7 ± 45.3 ?molHCl/2 h, P < 0.05) were increased markedly. Gastric wall mucussecretion was decreased (1.35 ± 0.08 vs 2.21 ± 0.11, P< 0.01), while the frequency of gastric contraction (1.2 ± 0.2 vs0.4 ± 0.1, P < 0.01), the width of contractive wave (17.2 ±2.0 vs 8.1 ± 1.1, P < 0.01), and the motility index perminute (90.3 ± 14.2 vs 13.2 ± 3.1, P < 0.01) wereelevated significantly. The administration of TRH antiserum significantlyinhibited the gastric mucosa damage caused by cold restraint stress (ulcerindex: 10 ......
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