关键词: 加速度;组织病理;组织超微结构;脑;大鼠

    摘 要:目的 探讨不同G值重复暴露后大鼠脑神经元损伤及其区域分布特点. 方法 将53只雄性SD大鼠随机分为对照组、+2Gz，+6Gz，+10Gz和+10Gy暴露组.分别在暴露后6h，1d，3d处死取脑，做石蜡或电镜超薄切片，利用光镜和电镜，观察不同G值重复暴露后，脑神经元形态学和超微结构的变化. 结果 +2Gz重复暴露组无明显的脑神经元形态学变化.+6Gz重复暴露后6h可见脑神经元超微结构的轻度变化，24h恢复正常.+10Gz和+10Gy重复暴露后，分别在海马CA1区、下丘脑、梨状皮层和左颞叶皮层、左梨状皮层，可见一定数量的变性神经元及重度的超微结构损伤. 结论 高G值重复暴露可引起大鼠特定脑区的神经元损伤，可能系机械力所致.

    Effect of repeated+Gz exposures on rats forebrain

    LI Jin-Sheng，SUN Xi-Qing，WUXing-Yu，HAN Lei，XIE Xiao-Ping，WU Yian-Hong

    Department of Aerospace Biodynamics，Faculty of Aerospace Medicine，Fourth Military Medical Uni-versity，Xi'an710033，China

    Keywords:acceleration;histopathology;ultrastructure;brain;rats

    Abstract:AIM To investigate the area distribution peculiar-ity of rats brain injury after repeated+Gz exposures.METHODS 53SD male rats were divided into control group，+2Gz，+6Gz，+10Gz and+10Gy exposure group.Rats brains were taken6h，1d or3d after+Gz ex-posure run for histopathologic and ultrastructure studies by light microscope and electron microscope.RESULTS There were not obvious changes of neuron morphology after repeat-ed+2Gz exposures.At6h after repeated+6Gz expo-sures ......