关键词: 乳腺癌;辅助化疗;时机

    摘 要:目的 对乳腺癌术后立即辅助化疗的安全性进行探讨. 方法 将32例行简化根治术的Ⅱ期乳腺癌患者随机分为2组，分别于术后第1日和第8日开始辅助化疗，观察其对术后切口愈合状况、化疗反应情况和血清IL-2，sIL-2R的影响. 结果 两组切口愈合状况无明显差异，化疗后2组均有少数患者出现恶心、呕吐现象经对症处理后症状基本消失，白细胞水平下降不显著，术后2组IL-2和sIL-2R的变化趋势相同. 结论 乳腺癌术后立即选择疗效好、副作用小的方案化疗，不影响切口愈合，不增加术后并发症，对患者的免疫功能影响不大，不会降低机体自身抗瘤能力，可提高乳腺癌的5a治愈率，减少术后复发率.

    Safety timing of early postoperative adjuvant chemotherapy in breast cancer

    LING Rui SHI Mei ZHANG Hong-Wei WANG Wei-Zhong

    1 Department of Gastrointestinal Surgery，

    2 Depertment of Radiation Therapy，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:breast cancer;adjuvant chemotherapy;timing

    Abstract:AIM To investigate the safety timing of immedi-ately postoperative chemotherapy in the patients with breast cancer.METHODS Thirty two patients with breast cancer of classificationⅡwere admitted to our hospital，were per-formed on a breast radical resection.The patients were divid-ed randomly into2groups and accepted chemotherapy at day1(group1)and day8(group2)after operation respectively，to observe the effect of healing of surgical wound ......