关键词: 鼻咽肿瘤;时间疗法;顺铂;氟尿嘧啶

    摘 要:目的 对比观察DDP联合5-FU的时辰化疗与常规化疗在同时期化、放疗应用过程中对晚期复发转移的鼻咽癌(nasopharyngeal carcinoma，NPC)的疗效. 方法 局部晚期复发转移的NPC患者50例，随机分为时辰化疗组(chrono-chemotherapy，CC)27例，常规化疗组(routine-chemothera-py，RC)23例，均采用同时期化、放疗措施. 结果 CC组为27例，其CR率、有效率(CR+PR)分别为18.5%，66.7%，中位生存期12mo(3～20mo).RC组为23例，其CR率、有效率(CR+PR)分别为8.7%，39.1%，中位生存期10mo(2.8～17mo).两组CR率及有效率(CR+PR)有显著性差异(P<0.05)，中位生存期无显著性差异(P>0.05).毒副反应比较结果:RC组相对于CC组口腔炎、恶心、呕吐、脱发更多见(P<0.05)，骨髓毒性反应亦有显著性差异(P<0.05). 结论 DDP联合5-FU的时辰化疗对晚期复发转移的NPC治疗效果较好，毒副反应较低，因此，同时期放疗与DDP联合5-FU的时辰化疗方案为晚期复发转移NPC较为有效的治疗方案.

    Therapeutic effect of chrono┐chemotherapy(DDP and5┐FU)with radiotherapy together for advanced or recurrent NPC

    YANG Xing-Long，REN Jun

    Center of Oncology，Xijing Hospital，Fourth Mili-tary Medical University，Xi'an710033，China

    Keywords:nasopharyngeal neoplasms;chronotherapy;cis-platin;fluorouracil

    Abstract:AIM While radiotherapy being taken，to compare the therapeutic effect of chrono-chemotherapy(DDP and5-FU)with routine-chemotherapy on advanced or recurrent

    NPC.METHODS Fifty patients with advanced and recur-rent NPC were divided randomly into2groups which included27cases in CC group(chrono-chemotherapy);and23cases in RC group(routine-chemotherapy).Both were treated with chemotherapy and radiotherapy together.RESULTS For CC group ......