关键词: 骨和骨组织;骨疾病，代谢性;婴儿，早产

    摘 要:目的 利用早产儿尸检的整块股骨，研究早产儿时期骨形成和吸收静态参数的变化，探讨早产儿代谢性骨病的发病机制. 方法 出生后1wk内死亡的早产儿21(男12，女9)例，胎龄25～36wk，出生体质量484～2445g，应用半自动计算机技术对骨皮质、骨小梁进行形态学测量. 结果 随着胎龄的增加，骨容积(BV/TV)明显增加，骨表面(BS/BV)，类骨质容积(OV/BV)和静止表面(RS/BS)明显减少;男性较女性的骨皮质形成参数OV/BV，Ob.S/BS，O.Th和骨吸收参数N.Oc/TAr明显增高;随着体质量的增加，Tb.Th，Vd.Th明显增加. 结论 早产儿骨吸收增加，骨形成减少，可能是早产儿发生代谢性骨病的主要机制.

    Static bone histomorphometry in preterm infants

    WANG Bao-Xi，ZHAO Xin，WANG Mao-Gui

    Department of Pediatrics，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:bone and bone tissue;infant，premature;bone diseases，metabolic

    Abstract:AIM To study parameters of bone formation and resorption，as well as the pathogenesis of metabolic bone dis-ease in premature infants.METHODS Using the semiauto-matic computerized technique to performed histomor-phometric analysis of trabecula and cortex of whole femora specimens.RESULTS With the growth of the fetus ......