关键词: U50488H;腹主动脉;内皮细胞;K+ ATP 通道;阿片肽;受体

    摘 要:目的 观察U50，488H(选择性κ-阿片受体激动剂)对大鼠腹主动脉的舒张作用，并探讨其机制. 方法 采用离体血管灌流实验，测定血管张力的改变. 结果 ①U50，488H对大鼠腹主动脉具有明显的舒张作用;②U50，488H对大鼠腹主动脉的舒张效应依赖于内皮细胞的存在;③优降糖可明显抑制U50，488H对大鼠腹主动脉的舒张作用;④U50，488H的舒张血管效应与M受体、β受体、前列腺素及NO无关. 结论 U50，488H是一种有效的扩血管物质，其舒张血管的效应具有内皮依赖性，且与K+ ATP 通道有密切关系.

    Relaxant effect of U50，488H on abdominal aorta in rats and its mechanism

    CHEN Mai1 ，PEI Jian-Ming2 ，LI Lan-Sun1 ，WANG Yue-Ming2 ，FAN Qian2 ，HUANG De-Ming3

    1 Department of Cardiovasology，Xijing Hospital，

    2 Department of Physiology，Faculty of Preclinical Medicine，Fourth Military Medical University，Xi'an710033，China，

    3 Department of Physiology，Medical School of Hong Kong University

    Keywords:U50488H;abdominal aorta;endothelium;K+ ATP channel;endogenous opioid peptides;receptors

    Abstract:AIM To investigate the relaxant effect of U50，488H(a selectiveκ-opioid receptor agonist)on abdominal aor-ta and its underlying mechanism in the rat.METHODS Iso-lated abdominal aorta was perfused and the tension of the vessel was measured.RESULTS ①U50，488H had the sig-nificant dose-dependent relaxant effect on rat abdominal aor-ta;②The relaxant effect of U50 ......