关键词: 重症肌无力;受体，胆碱能;抗体;基因，Fos;中枢神经系统

    摘 要:目的 探讨重症肌无力(MG)中枢神经系统(CNS)损害机制. 方法 从AChRab阳性的全身型MG患者血清中提取纯化IgG，然后注入大鼠侧脑室，应用免疫组织化学方法，观察即早基因c-fos的表达. 结果 脑室内注入AChRab后，大鼠皮层、海马、下丘脑等部位出现显著的Fos表达. 结论 c-fos基因参与MG中枢损害过程.研究表明皮层、海马、下丘脑等部的神经元极可能涉及MG中枢损害时的病理生理过程.

    Experimental study of c┐fos gene expression in ex┐perimental myasthenic model of central nervous sys┐tem dysfunction

    ZHU Lin，LI Zhu-Yi，WANG Zhe-Jine

    Department of Neurology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:myasthenia gravis;receptors，cholinergic;anti-bodies;genes，Fos;central nervous system;rats

    Abstract:AIM To explore the mechanism of central ner-vous system(CNS)dysfunction in myasthenia gravis(MG).METHODS c-fos expression was investigated in rat CNS neurons by immunohistochemical method following intracere-broventricular administration of IgG purified from MG pa-tient sera.RESULTS Strong expression of Fos was found in the cerebral cortex，hippocampus，hypothalamus et al after intracerebroventricular administration of IgG(AChab).CONCLUSION It is concluded that c-fos may be related to the mechanism of CNS dysfunction in MG. ......