心钠素对兔油酸型急性肺损伤血及支气管肺泡灌洗液中TNF┐α,IL┐8,ET┐1含量的影响
急性肺损伤,,急性肺损伤;心钠素;肿瘤坏死因子;白细胞介素-8;内皮素-1;支气管肺泡灌洗,0引言,1材料和方法,2结果,3讨论,参考文献
关键词: 急性肺损伤;心钠素;肿瘤坏死因子;白细胞介素-8;内皮素-1;支气管肺泡灌洗摘 要:目的 探讨心钠素(ANP)对油酸型急性肺损伤(ALI)家兔血及支气管肺泡灌洗液(BALF)中TNF-α,IL-8和ET-1含量的影响. 方法 观察油酸型ALI家兔(n=6)ANP治疗前,后不同时间混合静脉血及BALF中上述3种因子含量的变化,并于实验结束后测定肺水质量分数. 结果 油酸致伤后30,60和120min血及BALF中TNF-α,IL-8和ET-1含量均显著增高(P<0.05~0.01),ANP治疗后各因子含量明显下降(P<0.05),并维持在低水平,肺水质量分数也显著降低(P<0.05). 结论 iv ANP可有效降低油酸致伤后血及BALF中TNF-α,IL-8,ET-1水平,抑制肺内炎症反应,减轻肺损伤.
Influences of intravenous infusion of cardionatrin on TNF┐α,IL┐8and ET┐1contents in blood and bronchio┐alveolar lavage fluid of rabbits with acute lung injury induced by oleic acid
LIN Yun-Xin ZHANG Bing-Fang QI Hao-Wen LI Zhi-Chao JIA Bing
1 Department of Respiratory Diseases,473Hospital of Chinese PLA,Lanzhou730070,China,
2 Department of Respiratory Diseases,Xijng Hospi-tal,
3 Department of Pathophysiology,Faculty of Precinical Medicine,Fourth Military Medical Uni-versity
Keywords:acute lung injury;atrial natriuretic peptide;tu-mour necrosis factor;interleukin-8;endothelin-1;bronchoalveolar lavage
Abstract:AIM To investigate the effects of atrial natriuret-ic peptide(ANP)on the levels of TNF-α ......
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