关键词: 角朊细胞;增生性瘢痕;瘢痕疙瘩;粘附分子;免疫病理学

    摘 要:目的 探讨增生性瘢痕(HS)和瘢痕疙瘩(Ks)，角朊细胞(KC)表达ICAM-1和HLA-DR)，及≤1mo的HS(HS1)，2～6mo的HS(HS2)和7～24mo的HS(HS3)标本，分别作抗ICAM-1，HLA-DR，CD3 ，CD4 和CD8 的McAb的SABC方法免疫组化染色和观察. 结果 各组KC表达I-CAM-1和HLA-DR抗原的阳性检出率(%)、CD3+ 细胞密度(cells/mm2 )及CD4+ /CD8+ 比值(x ±s)，并作统计学处理.各组标本的KC表达ICAM-1和HLA-DR抗原的阳性检出率依次为:Ks-I>Ks-P>Ks-A，HS1>HS2>HS3(t，P<0.05～0.001).各组KC表达ICAM-1和HLA-DR的阳性率与组织内浸润的CD3+ 细胞密度和CD 4+ /CD8+ 比值呈明显正相关(P<0.05～0.01，r=0.249～0.324). 结论 KS和HS的KC通过表达ICMA-1和HLA-DR抗原，诱导T细胞浸润，上调局部免疫炎性反应，可能是病理性瘢痕形成的重要因素.

    Immunoinductive effect of keratinocyte in pathno┐logic scar

    JIANG Du-Yin，CHEN Bi，XU Ming-Da，TAO Ke Department of Burn Surgery，Plastic Surgery Cen-ter，Xijing Hospital，Fourth Military Medical Uni-versity，Xi'an710033，China

    Keywords:keratinocytes;hypertrophic scar;keloid;adhe-sion molecule;immunopathology

    Abstract:AIM To investigate the relationship between T lymphocytes and the ICAM-1and HLA-DR antigen expressed by keratinocytes(KC)of hypertrophic scars and keloids.

    METHODS Tissue samples were taken from different parts of keloids(Ks)i.e.invasive part(Ks-1) ......