关键词: 白细胞介素1;酵母;RNA;电离辐射;谷胱甘肽;超氧化物歧化酶;小鼠

    摘 要:目的 研究IL-1β(人重组白介素-1)复合酵母RNA对小鼠受γ射线外照射后外周血、肝、脾谷胱甘肽(GSH)和超氧化物歧化酶(SOD)活性的影响，探讨药物治疗辐射损伤机制. 方法 雌性小鼠25只，随机分为5组，1150cGy腹部照射后1h，24h分别给予后肢im IL-1β，酵母RNA，IL-1β复合酵母RNA，于照后6d，取外周血、肝脏和脾脏测SOD，GSH活性. 结果 照射后外周血、肝、脾SOD，GSH活性下降.使用IL-1β，酵母RNA，IL-1β复合酵母RNA后照射组外周血、肝、脾SOD，GSH活性升高，且肝、脾的SOD，GSH活性与照射对照组之间有显著差异(P<0.05)，复合组肝脾SOD，GSH活性明显高于照射对照组具有显著差异(P<0.01)，高于照射单独给药组.外周血各照射组之间无显著差异. 结论 IL-1β复合酵母RNA升高γ射线外照射对肝、脾谷胱甘肽(GSH)，超氧化物歧化酶(SOD)活性，复合用药可以对抗射线引起机体产生的损伤作用.结果表明:照后复合应用IL-1β，酵母RNA可通过提高清除自由基，起到更好的抗辐射作用.

    IL┐1βwith yeast RNA affects activity of glutathione and superoxide dismutase in blood lever and spleen in mice afterγ┐irradiation

    TIAN Fu-Rong ZENG Gui-Ying GU Xiao-Gang

    1 Department of Radiation Medicine，

    2 Department of Toxicology，Faculty of Preventive Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:interleukin1;yeast;RNA;γ-irradiation;glu-tathione;superoxide dismutase;mice

    Abstract:AIM To study mechanism of IL-1βwith yeast

    RNA to protect against irradiation.METHODS Twenty-five BALB/c female mice were abdominal irradiated with1150cGy ......