关键词: 下丘脑;基因，Fos;神经胶质原纤维酸性蛋白;失重模拟

    摘 要:目的 了解长期模拟失重状态下大鼠下丘脑功能活动状态. 方法 用Fos和胶质原纤维酸性蛋白(GFAP)的ABC法，分别检测4周模拟失重大鼠下丘脑神经元和星形胶质细胞(AS)的变化. 结果 二者表达仅见于室旁核尤其大细胞部、视上核和视交叉上核，而其它部位未见表达;AS胞体变大、突起增粗增长. 结论 下丘脑这些核团参与了对长期失重的反应，且可能与加压素分泌增加有关.

    Fos and GFAP expression in different parts of hy┐pothalamus in simulated weightlessness in rats

    SU Chang-Jun RAO Zhi-Ren ZHANG Li-Fan

    1 Department of Neurology，Tangdu Hospital，Xi'an710038，China，

    2 Institute of Neuroscience of Chi-nese PLA，

    3 Department of Aerospace Physiology，Faculty of Aerospace Medicine，Fourth Military Medical University

    Keywords:hypothalamus;gene，Fos;glial fibrillary acidic protein;weightlessness simulation

    Abstract:AIM To research the functions of rat hypothala-mus under long-term simulated weightlessness condition.METHODS By using anti-Fos and anti-GFAP immunohis-tochemical ABC methods，we observed changes of hypothala-mus neurons and astrocytes in4wk simulated rats.RE┐SULTS Expressions of Fos-and GFAP-positive cells were only found in paravetricular nuclei of the hypothalamus，es-pecially in mango cellular part ......