关键词: 肾移植;HLA抗原;抗体生成

    摘 要:目的 探讨肾移植受者HLA体液致敏的形成原因. 方法 应用ELISA方法对199例(男133例，女66例)肾移植等候者血中HLA抗体进行检测，分析与年龄、性别、透析时间、移植史、输血次数、妊娠史的关系. 结果 HLA体液致敏的分布在女性组高于男性组(32%vs17%，P<0.05);在输血组高于无输血组(43%vs6%，P<0.001);在透析时间≥1a组高于透析时间<1a组(43%vs20%，P<0.05);在有移植史组高于无移植史组(91%vs32%，P<0.001);在有妊娠组高于无妊娠组(40%vs8%，确切概率法P=0.021). 结论 输血、移植、长期透析、妊娠是肾移植受者致敏的重要因素.

    Factors resulting in HLA humoral sensitization in candidates of renal recipients

    WANG Bin，FENG Xin-Shun，XUE Wu-Jun，TIAN Pu-Xun，DING Xiao-Ming，XIANG He-Li Department of Renal Transplantation，First Hospi-tal，Xi'an Jiaotong University，Xi'an710061，China

    Keywords:renal transplantation;HLA antigens;antibody formation

    Abstract:AIM To study the causes of HLA sensitization.METHODS Anti-HLA antibodies in199cases waiting for renal transplantation were detected by ELISA assay to anal-yse the relationship between sensitization and other factors such as age ......