关键词: 肺/损伤;降钙素基因相关肽;肿瘤坏死因子;白细胞介素8;内皮缩血素-11

    摘 要:目的 探讨降钙素基因相关肽(CGRP)对油酸型急性肺损伤(acute lung injury，ALI)家兔血与支气管肺泡灌洗液(BALF)中TNF-α，IL-8和ET-1含量的影响. 方法 观察油酸型ALI家兔CGRP治疗前、后不同时间静脉血与BALF中上述3种细胞因子的含量，并测定其肺含水量. 结果 油酸致伤后30，60，120min血及BALF中TNF-α，IL-8和ET-1含量均显著增高(P<0.05～0.01)，尤其以TNF-α增幅最大.CGRP治疗后各因子含量明显下降(P<0.05)，并维持在低水平，肺含水量也显著降低(P<0.05). 结论 静脉注射CGRP可有效降低油酸致伤后血及BALF中TNF-α，IL-8和ET-1水平，抑制肺内炎症反应，减轻肺损伤.

    Effects of calcitonin gene┐related peptide on TNF┐α，IL┐8and ET┐1concentration in blood and bron┐chio┐alveolar lavage fluid of rabbits with acute lung injury induced by oleic acid

    ZHANG Bing-Fang ，LIN Yun-Xin ，QI Hao-Wen ，LI Zhi-Chao ，XUE Jun ，JIA Bin ，ZHAO Shu-Hua

    1 Department of Respiratory Diseases，Xijing Hospi-tal，3 Department of Pathophysiology，Faculty of Preclinical Medicine，Fourth Military Medical Uni-versity，Xi'an710033，China，2 Department of Res-piratory Medicine，473Hospital of Chinese PLA，Lanzhou730070，China

    Keywords:lung/injuries;calcitonin gene-related peptide;tu-mour necrosis factor;interleukin-8;endothelin-1 ......