【摘要】 目的 探讨E2F-1蛋白在胃癌及正常胃黏膜组织中的表达与意义。方法 采用免疫组化技术对80例原发性胃癌癌组织与癌旁黏膜中E2F-1的表达进行检测，同时对40例正常胃黏膜组织进行对照性研究，并进行统计学分析。结果 E2F-1在癌组织与癌旁黏膜中的阳性表达率为72.5%(58/80)和30.0%(24/80)，在正常胃黏膜组织中的阳性表达率为22.5%(9/40)，差异有非常显著性(P<0.001)。癌组织、癌旁黏膜中E2F-1的表达在不同的临床病理特征之间差异无显著性(P>0.05)。结论 E2F-1蛋白在胃癌组织中超表达，E2F-1的反常表达与胃癌的发生有关。

    【关键词】 胃癌；免疫组化；E2F-1

    Expression and significance of the E2F-1 in human gastric carcinomas

    XIAO Qiang,XIA Ke-yi,XV Jun-yi.

    Department of Gastrointestinal and Gland Surgery,The First Affiliated Hospital,Guangxi Medical University,Nanning 530027,China

    【Abstract】 Objective To study the expression and significance of E2F-1 in human primary gastric carcinomas and normal mucosa.Methods Immunohistochemistry was used to detect the expression of E2F-1 in the cancer tissues and their corresponding mucosa of 80 cases of human primary gastric carcinomas and to study by comparing with normal stomach mucosa of 40 cases.Statistics was used to analyze the data.Results The positive expression rate of E2F-1 in cancer tissues was 72.5%(58/80) ......