【摘要】 骨髓间充质干细胞是存在于骨髓中的一种具有跨胚层分化潜能的干细胞。近年来研究发现其可在中枢神经系统内存活并能分化为神经样细胞,在体外也可通过诱导向神经细胞转化,并对脑缺血、脑外伤等疾病的神经功能的缺损有改善作用。其取材方便、体外扩增迅速且能以多种途径移植包括静脉移植、脑内移植。故骨髓间充质干细胞在中枢神经系统损伤修复中的临床应用前景广阔。

    【关键词】 骨髓间充质干细胞；脑缺血；移植

    【Abstract】 Mesenchymal stem cells (MSCs) are stem cells that lying in marrow .The research showed that the cells could survive and were induced to divide so as to be confirmed as neural stem cells (NSCs) in vivo and ex vivo as so. It could be used to replace the neural cells or repair the nervous system,such as ischemic stroke, brain injury and so on. MSCs was easly grained and cultured,and there were various method of such as vein transplantation,directed transplantation. It provides a hopeful method for central nervous system diseases.

    【Key words】 mesenchymal stem cells;ischemic attack;transplantation

    脑血管疾病(cerebrovascular disease,CVD)是由于各种脑血管病变所引起的脑部病变。其中以缺血性脑血管病为主，其发病率、致残率、死亡率随年龄增长而增长，因病因、发病机制复杂，所采取的干预措施如早期溶栓等仍存在着局限性，使缺血性脑血管病的治疗状况得到根本改善的相关研究仍待进一步深入。自1992年Reynolds和Weiss从成年鼠海马分离出神经干细胞(neural stem cells，NSCs)，打破了传统观点认为在成年中枢神经系统(central nervous system ......