【摘要】 目的 探讨洛伐他汀及阿司匹林对冠心病患者C-反应蛋白的影响。方法 观察109例冠心病患者的C-反应蛋白在用药前后的变化。其中洛伐他汀组37例，阿司匹林组29例，洛伐他汀和阿司匹林联用组43例。结果 3组患者用药前后C-反应蛋白的改变差异均有显著性(P<0.05)，而洛伐他汀及阿司匹林联用组用药后C-反应蛋白的浓度与另两组用药后C-反应蛋白的浓度比较差异亦有非常显著性(P<0.01)。结论 洛伐他汀和阿司匹林联用对C-反应蛋白的降低优于单一的洛伐他汀或阿司匹林。

    【关键词】 C-反应蛋白；冠心病；洛伐他汀；阿司匹林

    The effects of lovastatin and aspirin on C-reactive protein in patients with coronary artery disease

    ZHENG Xiao-hui,HAO Zeng-guang,WANG Yan-fang.

    Anyang Reqion Hospital,Henan 455000,China

    【Abstract】 Objective To study the effects of lovastatin and aspirin on C-reactive protein in patients with coronary artery disease.Methods The changes of CRP concentrations before and after the treatment in 109 patients with coronary artery disease were investigated.Among these patients,37 were in lovastatin group,29 in aspirin group and 43 in lovastatin and aspirin group.Results The CRP concentrations in the three groups after the treatment were significantly lower than those before the treatment.In addition,the CRP in lovastatin and aspirin group were significantly lower than those in the other two groups after the treatment(P<0.01).Conclusion The reduction effects of lovastatin and aspirin on CRP concentrations were superior to those of single lovastatin or aspirin. ......