【摘要】 目的 验证肉毒毒素治疗贲门失弛缓症(AC)的疗效，提出延长药效的优化方案。方法 对16例贲门失弛缓症的病人进行内镜下肉毒毒素环形点注后临床观察。结果 通过内镜注药治疗前后症状积分降低与贲门扩张程度差异均有非常显著性(P<0.001)。反转注射法与常规法、定期复注与单注法2项比较，其延长疗效作用差异均有显著性(P<0.05)。结论 肉毒毒素治疗AC是有效的疗法，而针头刺入深度、定期复注和反转注射法等优化方案，是治疗AC更为有效而实用的途径。

    【关键词】 肉毒毒素；贲门失弛缓症；环形点注

    Clinical studies on botulin toxin in curing achalasia of the cardia

    WANG Chun,NING Qiang,ZHANG Bo-lun.

    Department of Gastroenterology,The Third Hospital of Wafangdian City,Dalian 116300 China.

    【Abstract】 Objective Botulin toxin has been widely applied to cure achalasia of the cardia at home and abroad.But how to prolong and to enhance its effects is controversial.Methods In our research,sixteen patients diagnosed as achalasia of the cardia were investigated after local annular injection.Results It has been discovered that dysphagia was ameliorated for cardiac sphincter dilating quickly induced by this cure.There was a significant difference between the symptoms that of curing ahead and curing behind (P<0.001).And the efficiency of this remedy is 93.6%.It is showed that this treatment is safety and effective method.Twelve patients diagnosed as achalasia of the cardia were followed up to improve its curative effects.Conclusions It is clearly demonstrated that the optimized therapy composed of regulating the vertical injection depth,reverse injection and periodical injecting to recrudescent patients is a more effective and practical method by clinical studies. ......