Protective effects of Qidantongmai tablet on platelet function in rats with myocardial injury

    LONG Yin, LIU Li, WANG Zongª²Ren, XIA Tian, MA Shiª²Ping, CHEN Xueª²Fu, MEI Qiª²Bing, YAN Peiª²Song

    Department of Traditional Chinese Medicine, Department of Pharmaceutics, Department of Pathology, Xijing Hospital, Department of Pharmacology, Faculty of Preclinical Medicine, Forth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To study the effects of Qidantongmai tablet (QDTMT ), a compound preparation made up of pure traditional Chinese medicine, on platelet function in rats with myocardial injury. METHODS: The suspension of QDTMT was administered to SD rats by gastrogavage for 14 days and from the 12th day rats were given subcutaneous injection of isoproterenol (ISO, 48 ¦Ìmol¡¤kg-1d-1) once per day for three days, thus establishing the myocardial injury model. RESULTS: Compared with model group, the group treated with QDTMT markedly alleviated the myocardial injury, inhibited platelet aggregation, decreased thromboxane B2(TXB2)level and increased 6ª²ketoª²prostaglandinª²F1¦Á (6ª²ketoª²PGF1¦Á) level and 6ª²ketoª²PGF1¦Á/TXB2 ratio (P<0.05, 0.05, 0.05, 0.01). CONCLUSION: The results show that QDTMT can inhibit the activation of platelet function and regulate the equilibrium of prostaglandin and thromboxane to prevent myocardial injury. ......