关键词: 玻璃体视网膜病变，增生性;单核细胞化学吸引蛋白质-1;巨噬细胞;T-淋巴细胞;免疫组织化学

    摘 要:目的 增生性玻璃体视网膜病变(PVR)是多种细胞和细胞因子参与的一种眼内创伤修复反应.单核细胞趋化蛋白-1(MCP-1)对巨噬细胞和淋巴细胞有特异趋化作用.本研究目的在于了解视网膜脱离后不同时期的组织中MCP-1的表达与巨噬细胞和淋巴细胞的关系. 方法 选用视网膜手术取材标本，包括孔源性视网膜脱离的视网膜下液中的细胞成份，B级PVR玻璃体手术集取物以及PVR C/D的视网膜增殖膜，免疫组化法检测其中MCP-1，CD68 和CD3 表达状态. 结果 视网膜下液中细胞成份MCP-1的表达均为阴性或弱阳性，B级PVR手术集取物以及增殖膜中，MCP-1表达阳性程度随PVR等级的升高而逐渐增高.CD68 阳性细胞(巨噬细胞)与CD3 阳性细胞(T-淋巴细胞)的比例随PVR病变程度的增加而降低. 结论 MCP-1对视网膜脱离后的愈合过程和PVR增殖膜的形成有调节作用.

    Significance of monocyte chemotactic protein┐1in specimens of proliferative vitreoretinopathy

    HAN Quan-Hong，HUI Yan-Hian，SHI Yi-Ning，MA Ji-Xian，DU Hong-Jun

    Department of Ophthalmology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:vitreoretinopathy，proliferative;monocyte chemoatlractant protein-1;macrophages;t-lymphocytes;immunohistochemistry

    Abstract:AIM To investigate the relationship between the presence of MCP-1and macrophages and T-lymphocytes in specimens obtained from retinal detachment and PVR eyes.

    METHODS Specimens were obtained during retinal surgery，including cellular components of subretinal fluids in rhegmatogenous retinal detachment(RD) ......