Influential factors of Technetiumª²99m labeled anticardiac myosin light mAb uptake in infarcted myocardium in rats

    WU Qiang, LI Xiaoª²Ying

    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China

    ¡¾Abstract¡¿ AIM: To study the influential factors of uptake of Technetiumª²99m labeled anticardic myosin light chain monoclonal antibody (99Tcmª²AMLCA) in infarcted myocardium in rats. METHODS: The ratio was calculated between infarcted and normal myocardium after injecting certian dose of 99Tcmª²AMLCA in the experimental myocardial infarction in rats and the relationship was observed between the radioactivity uptake in infarcted myocardium and injection time, infarction time and zone region of infracted myocardium. RESULTS: The infarcted myocardium uptook 99Tcmª²AMLCA rapidly at the first 2 h, increased towards steady at 4¡«8 h and reached the peak at 24 h after injection. Compared with the ratios of 99Tcmª²Nª²IgG in the infarcted with normal myocardium, the ratios of 99Tcmª²AMLCA were significantly higher at the same time after injection (P<0.01). There were a greater uptake of 99Tcmª²AMLCA in the infarcted myocardium during the phase of acute myocardium infarction (AMI).The uptake of 99Tcmª²AMLCA in the infarcted myocardium in the endiocardial layers at the infarct center was greater than other zone regions of infracted myocardium. CONCLUSION: The uptake of 99Tcmª²AMLCA is specific, rapid and long lasting in the infarcted myocardium and is hardly affected by infarct time. This may probably become a new approach to myocardial infarct imaging. ......