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幽门螺杆菌阳性消化性溃疡患者胃黏膜核因子κB、b- 防御素 -2 表达及其与胃窦炎症的关系
http://www.100md.com 凌江红, 李家邦, 聂海明, 蒋荣鑫, 申定珠,
幽门螺杆菌;消化性溃疡;核因子κB;b-防御素-2;炎症,幽门螺杆菌阳性消化性溃疡患者胃黏膜核因子κB、b-防御素-2表达及其与胃窦炎症的关系,凌江红,李家邦,蒋荣鑫,申定珠,聂海明,韦宗平,凌江
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     凌江红, 李家邦, 蒋荣鑫, 申定珠, 中南大学湘雅医院中西医结合研究所 湖南省长沙市 410008

    聂海明, 韦宗平, 广西医科大学第一附属医院消化内科 广西省南宁市 530021

    凌江红, 女, 1969-05-17生, 广西省合山市人, 汉族, 中南大学湘雅医院博士, 副教授, 副主任医师, 主要从事内科消化系统疾病的中西医结合诊断与治疗.

    湖南省科技计划重点项目, No. 02SSY1005-4

    通讯作者: 李家邦, 410008, 湖南省长沙市湘雅路141号, 中南大学湘雅医院中西医结合研究所. ljh001006@sina.com

    电话: 0731-4327227

    收稿日期: 2005-11-15 接受日期: 2005-12-24

    Expression of nuclear factor-kappa B and β-defensin-2 in patients with Helicobacter pylori-positive peptic ulcer and their relations with antral gastritis

    Jiang-Hong Ling, Jia-Bang Li, Hai-Ming Nie, Rong-Xin Jiang, Ding-Zhu Shen, Zong-Ping Wei

    Jiang-Hong Ling, Jia-Bang Li, Rong-Xin Jiang, Ding-Zhu Shen, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China

    Hai-Ming Nie, Zong-Ping Wei, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China

    Supported by the Fund from the Key Science and Technology Plan of Hunan Province, No. 02SSY1005-4

    Correspondence to: Dr. Jia-Bang Li, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 141 Xiangya Road, Changsha 410008, Hunan Province, China. ljh001006@sina.com

    Received: 2005-11-15 Accepted: 2005-12-24

    Abstract

    AIM: To investigate the roles of nuclear factor kappa B (NF-κB), humanb-defensin-2 (HBD-2) and antral gastritis in H pylori-positive peptic ulcer (PU).

    METHODS: Patients with H pylori-positive (n = 40) or H pylori-negative (n = 17) PU were included in this study. Eight individual were selected as normal controls. Antral histopathology was observed in the patients and controls. The expression of NF-κBp65 andb-denfensin-2 were measured by immunohistochemistry, and then compared between H pylori-positive and negative patients and normal group as well as between patients with different stages of PU by One-Way ANOVA. Nonparametric statistics was used to analyze the correlations of H pylori infection, NF-κBp65, HBD-2 expression with the degree of antral gastritis. Meanwhile, the relationship between expression of NF-κBp65 and HBD-2 was also analyzed in H pylori-positive PU.

    RESULTS: The histological severities of both active and chronic inflammation were correlated with H pylori density (active: r = 0.374, P < 0.01; chronic: r = 0.333, P < 0.05). NF-κBp65 was expressed mainly in the nucleus of gastric epithelial and mesenchymal cells in lamina propria while HBD-2 was expressed mainly in the cytoplasm of the surface cells of gastric mucosal epithelium. The expression of NF-κBp65 and HBD-2 were significantly higher in H pylori-positive patients than those in H pylori-negative ones (6.4 ± 3.28 vs 3.78 ± 2.16, P < 0.01; 12.96 ± 5.03 vs 4.69 ± 2.05, P < 0.01), and both expression of NF-κBp65 and HBD-2 were correlated with histological severity of active and chronic inflammation (active: r = 0 ......

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