胃癌组织中KAI1、nm23及P53的表达及其临床意义
http://www.100md.com
刘茗露, 刘斌, 邢传平, 陈一伟
胃癌;KAI1;nm23;P53;免疫组织化学,刘茗露,刘斌,邢传平,陈一伟,通讯作者:,BinLiu,Chuan-PingXing,Yi-
 |
| 第3页 |
 |
| 第1页 |
参见附件(1401KB，6页)。
刘茗露, 兰州大学基础医院病理研究所 甘肃省兰州市 730020
刘斌, 邢传平, 陈一伟, 兰州军区兰州总医院 甘肃省兰州市 730050
通讯作者: 刘斌, 兰州军区兰州总医院病理科 甘肃省兰州市 730050 Liumb@public.lz.gs.cn
电话: 0931-8975406 传真: 0931-8975404
收稿日期: 2005-11-30 接受日期: 2006-12-19
Expression of KAI1, nm23 and P53 in Gastric Carcinoma and Their Clinical Significances
Ming-Lu Liu, Bin Liu, Chuan-Ping Xing, Yi-Wei Chen
Ming-Lu Liu, Institute of Pathology, Basic Medicine of Lanzhou University, Lanzhou 730020, Gansu Province, China
Bin Liu, Chuan-Ping Xing, Yi-Wei Chen,General Hospital of Lanzhou Military Command, Chinese PLA, Lanzhou 730050, Gansu Province, China
Correspondence to:Department of Pathology, General Hospital of Lanzhou Military Command, Chinese PLA, Lanzhou 730050, Gansu Province, China.liumb@public.lz.gs.cn
Received: 2005-11-30 Accepted:2005-12-19
Abstract
AIM:To investigate the expression of KAI1, nm23 and P53 protein as well as their significances in the development of gastric carcinoma.
METHODS: The expression of KAI1, nm23 and P53 protein were detected by SP immunohistochemistry in gastric atypical hyperplasia (n = 65), gastric carcinoma (n = 74) and normal gastric tissues (n = 22).
RESULTS: The positive rates of KAI1 and nm23 protein expression were decreased with the malignancy of gastric tissues, and there were significantly differences between normal gastric tissues, atypical hyperplasia and carcinoma (KAI1: c2 = 20.885, P < 0.001; nm23: c2 = 29.133, P < 0.05), while the positive rate of P53 protein expression was in the opposite tendency (c2 = 21.954, P < 0.001). The expression of KAI1, nm23 and P53 protein were notably correlated with the depth of invasion, lymph nodes metastasis and vessel invasion (c2 = 20.885, P < 0.001; c2 = 29.133, P < 0.05; c2 = 21.954, P < 0.001), but they were not correlated with the age and gender of patients ......
您现在查看是摘要介绍页，详见PDF附件(1401KB，6页)。