Protective effects of salvia miltiorrhiza and verapamil on high energy shock wave induced renal damage in rabbits

    CHEN Xingª²Fa, SHENG Binª²Wu, HE Daª²Lin, NAN Xunª²Yi

    Department of Urology, First Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To study the protective effects of salvia miltiorrhiza on high energy shock wave induced renal damage in rabbits. METHODS: A total of 45 rabbits was randomly assigned to 3 groups. Control received physiological saline and the others received salvia miltiorrhiza and verapamil for 3 days before extracorporeal shock wave lithotripy (ESWL), respectively. Plasma ETª²1, SOD and serum MDA were measured. RESULTS: After ESWL, there was a significant increase in plasma ETª²1 (P=0.015) and serum MDA levels (P=0.01) and the activity of SOD in plasma decreased significantly (P=0.003) compared with that before ESWL in control. In salvia miltiorrhiza and verapamil groups, however, plasma ETª²1 and serum MDA after ESWL were not significantly different compared with the values before ESWL and were significantly lower than those of the controlled groups. Although the levels of the plasma SOD after ESWL decreased compared with the preª²ESWL levels, the activity of SOD in plasma was significantly higher than that of the controlled ones (salvia miltiorrhiza: P=0.001, verapamil: P=0.022). All parameters were not significantly different between salvia miltiorrhiza and verapamil groups. CONCLUSION: Salvia miltiorrhiza and verapamil both have protective effects on shockwaveª²induced renal injury in rabbits. ......