脑血管意外__(期刊论文)

急性脑血管病患者血清hsCRP, TNFα和IL6的动态变化及临床意义

http://www.100md.com 《第四军医大学学报》 2004年第2期

脑血管意外,,急性病；脑血管意外；C反应蛋白；肿瘤坏死因子；白细胞介素6,急性脑血管病患者血清hsCRP,TNFα和IL6的动态变化及临床意义,0引言,1对象和方法,2结果,3讨论,【参考

     Dynamic changes of serum hsCRP, TNFα, IL6 in acute cerebral vessel disease patients and their clinical significance

    CAO JiaoFei, LIU Ning, LIANG DeSheng, PEI ShiCheng

    Department of Neurology, Second Affiliated Hospital, Lanzhou Medical College, Lanzhou 730030, China

    【Abstract】 AIM: To study the dynamic changes of serum high sensitivity Creactive protein (hsCRP), interleukin6 (IL6) and tumor necrosis factorα (TNFα), which lead to inflammatory and/or immunological dysfunctions in the patients suffering from acute cerebral vessel disease (ACVD). METHODS: Serum hsCRP level detected by ELISA and TNFα and IL6 levels detected by RIA were determined at the 1st, 3rd, 7th and 15th d from 70 ACVD patients and from 30 agematching healthy persons as control. Data of each parameter investigated were analyzed for statistical difference between cases and control group by ttest, and correlation between the levels of the markers at different times were compared. Analysis of variance(ANOVA) was performed on sample means. RESULTS: Levels of serum hsCRP, IL6 and TNFα at the 1st and 3rd d of cases were higher than those of the control group (P<0.01), but decreased at the 7th d and restored to normal at the 15th d. These three markers were positively correlated to the early stage of ACVD as well as stroke severity(r>0.5, P<0.05). CONCLUSION: HsCRP, IL6 and TNFα participate in initiation and propagation steps of ACVD. It inferred that the respective antagonists of hsCRP, IL6 and TNFα may possess a high potential as the treatment strategy for ACVD. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/02/19/87/12/30.htm

您现在查看是摘要页，全文长 9108 字符。