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甘珀酸对大鼠脑皮质缺血后神经元损伤的影响
http://www.100md.com 《第四军医大学学报》 2004年第12期
脑缺血,,脑缺血;甘珀酸;缝隙接合部;大鼠;星形细胞,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Effects of carbenoxolone on neuron injury induced by focal cerebral infarct

    ZHANG GuangYun, DUAN Li, RAO ZhiRen, XU Yan

    1PLA Institute of Neuroscience, 2Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To explore the effects of carbenoxolone (CBX), a gap junction blocker, on the neuron injury induced by focal cerebral infarct. METHODS: Focal cerebral infarcts were produced by photothrombosis in adult rats. Immunohistochemical technique for antiFOS and antiGFAP, and Cresyl Violet staining were used in the present study. The volumes of focal cerebral infarct and the expressions of FOS and GFAP were studied 24 h after focal cerebral infarct. CBX(50 μg/200 g)was injected into the right lateral ventricle at 2h prior to the operation. RESULTS: The volumes of focal cerebral infarct and the expressions of FOS in the rats pretreated with CBX significantly decreased compared with those in the salinetreated control group (P<0.01). The GFAP positive astrocytes in both groups showed some changes in morphology, but with no significant difference between the two groups(P>0.05). CONCLUSION: The results suggest that CBX may play a role in protecting the neurons from damages induced by focal cerebral infarct. ......

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