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急性炎症状态对家兔急性心肌缺血的影响
http://www.100md.com 《第四军医大学学报》 2004年第7期
心肌缺血,,炎症反应;心肌缺血;心功能;环氧化酶2,0引言,1材料和方法,2结果,3讨论,【参考文献】
     Effects of experimental acute myocardial infarction (AMI) on rabbits with systemic inflammation

    LI Bo, YANG XinGuo, ZHENG QiangSun, LENG LiJuan, ZHANG LuXing, ZHOU ZhiGang

    1Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China, 2Xi’an Railroad Hospital, Xi’an 710054, China

    【Abstract】 AIM: To investigate the effects of experimental acute myocardial infarction (AMI) on rabbits with systemic inflammation. METHODS: Adult rabbits (weight: 1.8-2.5 kg; n=24) were randomly divided into 4 groups: group A: normal controls; group B: myocardial ischemia: The left circumflex arteries of rabbits were ligated to establish the animal models of AMI; group C: Lipopolysaccharide (LPS) and group D: myocardial ischemia + LPS. Six hours after AMI, the serum MDA, NO, MPO and ANP were measured and myocardial HE and COX2 expression were determined by immunohistochemical staining. RESULTS: Plasma MDA, NO and MPO increased significantly 6 h after AMI in groups B, C and D, and those in group D increased more significantly compared with those in groups B and C(P<0.05). ANP and LVEDP and LVPEP significantly increased in group D compared with those of group B(P<0.05). In group D, the myocardial COX2 expression was significantly higher than that in group B and C. CONCLUSION: Inflammatory factors damage the myocardium and aggravate the heart function. ......

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