急性炎症状态对家兔急性心肌缺血的影响
心肌缺血,,炎症反应;心肌缺血;心功能;环氧化酶2,0引言,1材料和方法,2结果,3讨论,【参考文献】
Effects of experimental acute myocardial infarction (AMI) on rabbits with systemic inflammationLI Bo, YANG XinGuo, ZHENG QiangSun, LENG LiJuan, ZHANG LuXing, ZHOU ZhiGang
1Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China, 2Xi’an Railroad Hospital, Xi’an 710054, China
【Abstract】 AIM: To investigate the effects of experimental acute myocardial infarction (AMI) on rabbits with systemic inflammation. METHODS: Adult rabbits (weight: 1.8-2.5 kg; n=24) were randomly divided into 4 groups: group A: normal controls; group B: myocardial ischemia: The left circumflex arteries of rabbits were ligated to establish the animal models of AMI; group C: Lipopolysaccharide (LPS) and group D: myocardial ischemia + LPS. Six hours after AMI, the serum MDA, NO, MPO and ANP were measured and myocardial HE and COX2 expression were determined by immunohistochemical staining. RESULTS: Plasma MDA, NO and MPO increased significantly 6 h after AMI in groups B, C and D, and those in group D increased more significantly compared with those in groups B and C(P<0.05). ANP and LVEDP and LVPEP significantly increased in group D compared with those of group B(P<0.05). In group D, the myocardial COX2 expression was significantly higher than that in group B and C. CONCLUSION: Inflammatory factors damage the myocardium and aggravate the heart function. ......
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