Neuroprotective effect of transient ischemic attacks on cerebral infarction

    WEN Xiaoª²Yan, LI Yanª²Hua

    Department of Clinical Laboratory, Liaocheng People¡¯s Hospital, Liaocheng 252000, China

    ¡¾Abstract¡¿ AIM: To evaluate the effect of transient ischemic attacks (TIA) on cerebral infarction volume and the production of excited amino acids (EAAs) of patients with cerebral infarction. METHODS: Sixty patients including 20 patients with firstª²ever cerebral infarction (Group CI), 20 firstª²ever cerebral infarction patients with prior ipsilateral TIA (Group TIA) and 20 control subjects (Group control) were involved in study. Using high performance liquid chromatography (HPLC), the concentrations of glutamate and aspartate in plasma and cerebrospinal fluid (CSF) in 3 groups were measured. The cerebral infarction volume of patients in Group CI and Group TIA were evaluated. RESULTS: The levels of glutamate and aspartate in plasma and in CSF were increased in Group CI comparing with Group control (P<0.05), and these were decreased in Group TIA comparing with Group CI (P<0.05). The infarction volume was smaller in Group TIA than in Group CI (P<0.05). In Group CI and Group TIA, the concentrations of glutamate and aspartate in plasma and CSF of TIA were positively correlated with infarction volume (r=0.905, P<0.01). CONCLUSION: TIA could decreased the secretion of EAAs and the infarction volume of patients with firstª²ever CI. TIA may have a neuroprotective effect on cerebral infarction. ......