Efficiency of intraª²arterial neoadjuvant chemotherapy before radical excision in 52 patients with cervical cancer

    Y¨¹ Yueª²Cheng, WANG Haiª²Dan, XIN Xiaoª²Yan, LI Guiª²Rong, ZHAO Haiª²Bo, Wang Bin

    1Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Xi¬ðan 710033, China, 2Center of Oncology, No. 82nd PLA Hospital, Huai¬ðan 223001, China

    ¡¾Abstract¡¿ AIM: To explore the feasibility and therapeutic efficiency of intraª²arterial neoadjuvant chemotherapy before radical excision in patients with cervical cancer. METHODS: Fiftyª²two female patients with cervical cancer were enrolled into the study and were treated with a 2ª²3ª²course of intraª²arterial neoadjuvant chemotherapy immediately after the pathological diagnosis. The regime included 50 mg/m2 DDP, 1000 mg/m2 5ª²FU and 20 mg/m2 MMC. Then radical excision was performed in those who were good for the operation. RESULTS: Complete recovery (CR) was acquired in 12 patients and partial recovery (PR) in 28 patients. The total response rate was 76.9%, with no recovery (NR) in 8 and progressed disease (PD) in 4 of 52 cases after 2 courses of intraª²arterial neoadjuvant chemotherapy. The tumor size reduced significantly (P<0.05) after neoadjuvant therapy and the radical excision was preformed successfully in 50 patients. Pathological examination revealed pelvic lymphatic metastasis in 1 of 12CR, 4 of 28 PR, and 8 of NR or PD. No serious side effects related to the chemotherapy or operation were observed in all the patients. CONCLUSION: Intraª²arterial neoadjuvant chemotherapy before radical excision not only is helpful for operation but also can reduce metastasis and recurrence. It can extend patients' survival time and improve life quality. ......